Like with many antidepressant medication, it’s not advisble to abruptly stop taking mirtazapine. Care must be taken, however, when deciding to stop taking the drug. Long term use of mirtazapine is considered safe, with little risk of long-term side effects even when the drug is taken for months or years. 5 What are the long term side effects of mirtazapine? Weight gain is also considered a common side-effect of mirtazapine, with one study on healthy males concluding that the drug may change the user’s metabolism slightly and increase cravings for sweet foods. It may also increase the occurrence of restless legs syndrome and periodic limb movements 4 both of which can significantly disrupt your sleep. It can also leave some people feeling groggy or feeling like they have a slight hangover, so following the prescribed dosage is very important. While mirtazapine may help you to sleep better while you’re taking it, it’s well recognised that insomnia can develop after stopping taking the drug.ĭue to its sedating effects, mirtazapine can lead to daytime drowsiness. It’s interesting to note that mirtazapine may cause ‘sleep disorders’, with fatigue also being a common side effect. diarrhoea, nausea, constipation and vomiting.dry mouth, joint pain, muscle aches and pains.increased appetite, water retention and weight gain.Side effects are not uncommon when taking mirtazapine and can include: While it may seem like off-label use of mirtazapine could help with insomnia, it’s not without its side-effects. It reduces the duration of early, light stages of sleep and increases deep sleep 2 and also slightly reduces REM sleep (dream sleep). Mirtazapine has been shown to affect different phases of sleep. Mirtazapine has been found to reduce the time it takes for a person to fall asleep 2 and night-time waking, while improving the continuity and overall quality of sleep. It’s not clear whether it’s the drug itself which reduces the symptoms of insomnia or whether, by reducing the severity of depressive symptoms, it has the knock-on effect of helping the person to sleep better. There’s some evidence that mirtazapine can be an effective treatment for insomnia in people with depression. Mirtazapine doesn’t stop the recycling of these messengers but instead blocks some of the receptors they interact with. Mirtazapine, like many other antidepressants, works by increasing the concentration of certain neurotransmitters (chemical messengers) in the brain but differs to many others on the market in just how it does that. Mirtazapine is still branded as Remeron in most countries but, as it’s no longer patented, generic versions are sold under various brand names around the world. It was launched in the United States in 1996 under the brand name Remeron. Mirtazapine was developed by the Dutch pharmaceutical company Organon and was first approved for its use in major depressive disorder in the Netherlands in 1994.
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